Yemen’s Houthi rebels fired an anti-ship cruise missile toward an American destroyer in the Red Sea on Sunday, but a US fighter jet shot it down in the latest attack roiling global shipping amid Israel’s war with Hamas in the Gaza Strip, officials said.

The attack marks the first US-acknowledged fire by the Houthis since America and allied nations began strikes Friday on the rebels following weeks of assaults on shipping in the Red Sea.

The Houthis have targeted that crucial corridor linking Asian and Mideast energy and cargo shipments to the Suez Canal onward to Europe over the Israel-Hamas war, attacks that threaten to widen that conflict into a regional conflagration.